This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedĭata Availability: All data are contained within the paper and its Supporting Information files.įunding: This study was supported in part by a NIH Grant No. Received: JanuAccepted: JPublished: August 10, 2015Ĭopyright: © 2015 Tian et al. Stanford University Medical Center, UNITED STATES We believe that OCTRIMA 3D is a leap forward towards achieving reliable, real-time analysis of 3D OCT retinal data.Ĭitation: Tian J, Varga B, Somfai GM, Lee W-H, Smiddy WE, Cabrera DeBuc D (2015) Real-Time Automatic Segmentation of Optical Coherence Tomography Volume Data of the Macular Region. The average unsigned error was about 1 pixel (∼ 4 microns), which was also lower compared to the reference algorithms. The processing time for the whole OCT volume of 496×644×51 voxels (captured by Spectralis SD-OCT) was 26.15 seconds which is at least a 2-8-fold increase in speed compared to other, similar reference algorithms used in the comparisons. Our segmentation algorithm was evaluated by comparing with the manual labelings and three state of the art graph-based segmentation methods. Additional techniques, such as inter-frame flattening, inter-frame search region refinement, masking and biasing were introduced to exploit the spatial dependency between adjacent frames for the reduction of the processing time. The proposed method is implemented using the shortest-path based graph search, which detects the retinal boundaries by searching the shortest-path between two end nodes using Dijkstra’s algorithm. In this work, we have developed an automatic algorithm, OCTRIMA 3D (OCT Retinal IMage Analysis 3D), that could segment OCT volume data in the macular region fast and accurately. The fast and automatic analysis of 3D volume OCT data is crucial taking into account the increased amount of patient-specific 3D imaging data. Optical coherence tomography (OCT) is a high speed, high resolution and non-invasive imaging modality that enables the capturing of the 3D structure of the retina.

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